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    Structured Review

    Carl Zeiss a1 zeiss

    A1 Zeiss, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 97/100, based on 1207 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/microscope+zeiss+vert+a1/Inverted+microscope+Axio+Vert%2EA1/pmc13690700-391-0-1
    Average 97 stars, based on 1207 article reviews
    a1 zeiss - by Bioz Stars, 2026-11
    97/100 stars

    Images

    1) Product Images from "In vivo replication of a fully functional nerve net in a clonally reproducing animal"

    Article Title: In vivo replication of a fully functional nerve net in a clonally reproducing animal

    Journal: Communications Biology

    doi: 10.1038/s42003-026-11184-x


    Figure Legend Snippet:

    Techniques Used:

    Related Articles

    Staining:

    Article Title: Data on the function of CDH17 in pancreatic cancer growth
    Article Snippet: How data was acquired , Microscope (Zeiss, Vert A1), mass spectrometry (Molecular Devices, iD3), GEPIA (Gene Expression Profiling Interactive Analysis: gepia.cancer-pku.cn/)..

    Article Title: Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity.
    Article Snippet: Aims: The present study aimed at exploring the mechanisms behind Klotho regulation in hyperglycemia augmented AKI.. In addition, epigenetic ways to restore the Klotho expression in AKI-diabetes comorbidity have


    Article Title: Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
    Article Snippet: Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their cooverexpression is strongly associated with a poor prognosis.. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.. Inspired by the PROteolysis TArgeting Chimera (PROTAC), a promising pharmacological modality for the selective degradation of proteins, we developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to degrade both β-catenin and STAT3 effectively.

    Article Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Article Snippet: Finally, the cells were observed under microscope (Zeiss Vert A1).

    Article Title: Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats.
    Article Snippet: Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD).. Currently, available therapies are not uniformly effective and lead to serious adverse effects.. Levosimendan (LVS), a calcium sensitizer and an inodilator, manages cardiac failure.


    Article Title: Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Article Snippet: The organoids were stained with fluorescence and photographed under microscope (Zeiss, Vert A1), and the area of live organoids was counted.

    Fluorescence:

    Article Title: Data on the function of CDH17 in pancreatic cancer growth
    Article Snippet: How data was acquired , Microscope (Zeiss, Vert A1), mass spectrometry (Molecular Devices, iD3), GEPIA (Gene Expression Profiling Interactive Analysis: gepia.cancer-pku.cn/)..

    Article Title: Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity.
    Article Snippet: Aims: The present study aimed at exploring the mechanisms behind Klotho regulation in hyperglycemia augmented AKI.. In addition, epigenetic ways to restore the Klotho expression in AKI-diabetes comorbidity have


    Article Title: Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
    Article Snippet: Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their cooverexpression is strongly associated with a poor prognosis.. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.. Inspired by the PROteolysis TArgeting Chimera (PROTAC), a promising pharmacological modality for the selective degradation of proteins, we developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to degrade both β-catenin and STAT3 effectively.

    Article Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Article Snippet: Finally, the cells were observed under microscope (Zeiss Vert A1).

    Article Title: Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats.
    Article Snippet: Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD).. Currently, available therapies are not uniformly effective and lead to serious adverse effects.. Levosimendan (LVS), a calcium sensitizer and an inodilator, manages cardiac failure.


    Article Title: Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Article Snippet: The organoids were stained with fluorescence and photographed under microscope (Zeiss, Vert A1), and the area of live organoids was counted.

    Microscopy:

    Article Title: Data on the function of CDH17 in pancreatic cancer growth
    Article Snippet: How data was acquired , Microscope (Zeiss, Vert A1), mass spectrometry (Molecular Devices, iD3), GEPIA (Gene Expression Profiling Interactive Analysis: gepia.cancer-pku.cn/)..

    Article Title: Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity.
    Article Snippet: Aims: The present study aimed at exploring the mechanisms behind Klotho regulation in hyperglycemia augmented AKI.. In addition, epigenetic ways to restore the Klotho expression in AKI-diabetes comorbidity have


    Article Title: Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
    Article Snippet: Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their cooverexpression is strongly associated with a poor prognosis.. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.. Inspired by the PROteolysis TArgeting Chimera (PROTAC), a promising pharmacological modality for the selective degradation of proteins, we developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to degrade both β-catenin and STAT3 effectively.

    Article Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Article Snippet: Finally, the cells were observed under microscope (Zeiss Vert A1).

    Article Title: Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats.
    Article Snippet: Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD).. Currently, available therapies are not uniformly effective and lead to serious adverse effects.. Levosimendan (LVS), a calcium sensitizer and an inodilator, manages cardiac failure.


    Article Title: Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Article Snippet: The organoids were stained with fluorescence and photographed under microscope (Zeiss, Vert A1), and the area of live organoids was counted.

    Inverted Microscopy:

    Article Title: Data on the function of CDH17 in pancreatic cancer growth
    Article Snippet: How data was acquired , Microscope (Zeiss, Vert A1), mass spectrometry (Molecular Devices, iD3), GEPIA (Gene Expression Profiling Interactive Analysis: gepia.cancer-pku.cn/)..

    Article Title: Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity.
    Article Snippet: Aims: The present study aimed at exploring the mechanisms behind Klotho regulation in hyperglycemia augmented AKI.. In addition, epigenetic ways to restore the Klotho expression in AKI-diabetes comorbidity have


    Article Title: Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
    Article Snippet: Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their cooverexpression is strongly associated with a poor prognosis.. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.. Inspired by the PROteolysis TArgeting Chimera (PROTAC), a promising pharmacological modality for the selective degradation of proteins, we developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to degrade both β-catenin and STAT3 effectively.

    Article Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Article Snippet: Finally, the cells were observed under microscope (Zeiss Vert A1).

    Article Title: Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats.
    Article Snippet: Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD).. Currently, available therapies are not uniformly effective and lead to serious adverse effects.. Levosimendan (LVS), a calcium sensitizer and an inodilator, manages cardiac failure.


    Article Title: Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Article Snippet: The organoids were stained with fluorescence and photographed under microscope (Zeiss, Vert A1), and the area of live organoids was counted.

    Isolation:

    Article Title: Data on the function of CDH17 in pancreatic cancer growth
    Article Snippet: How data was acquired , Microscope (Zeiss, Vert A1), mass spectrometry (Molecular Devices, iD3), GEPIA (Gene Expression Profiling Interactive Analysis: gepia.cancer-pku.cn/)..

    Article Title: Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity.
    Article Snippet: Aims: The present study aimed at exploring the mechanisms behind Klotho regulation in hyperglycemia augmented AKI.. In addition, epigenetic ways to restore the Klotho expression in AKI-diabetes comorbidity have


    Article Title: Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
    Article Snippet: Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their cooverexpression is strongly associated with a poor prognosis.. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.. Inspired by the PROteolysis TArgeting Chimera (PROTAC), a promising pharmacological modality for the selective degradation of proteins, we developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to degrade both β-catenin and STAT3 effectively.

    Article Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Article Snippet: Finally, the cells were observed under microscope (Zeiss Vert A1).

    Article Title: Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats.
    Article Snippet: Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD).. Currently, available therapies are not uniformly effective and lead to serious adverse effects.. Levosimendan (LVS), a calcium sensitizer and an inodilator, manages cardiac failure.


    Article Title: Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Article Snippet: The organoids were stained with fluorescence and photographed under microscope (Zeiss, Vert A1), and the area of live organoids was counted.

    Cell Culture:

    Article Title: Data on the function of CDH17 in pancreatic cancer growth
    Article Snippet: How data was acquired , Microscope (Zeiss, Vert A1), mass spectrometry (Molecular Devices, iD3), GEPIA (Gene Expression Profiling Interactive Analysis: gepia.cancer-pku.cn/)..

    Article Title: Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity.
    Article Snippet: Aims: The present study aimed at exploring the mechanisms behind Klotho regulation in hyperglycemia augmented AKI.. In addition, epigenetic ways to restore the Klotho expression in AKI-diabetes comorbidity have


    Article Title: Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
    Article Snippet: Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their cooverexpression is strongly associated with a poor prognosis.. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.. Inspired by the PROteolysis TArgeting Chimera (PROTAC), a promising pharmacological modality for the selective degradation of proteins, we developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to degrade both β-catenin and STAT3 effectively.

    Article Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Article Snippet: Finally, the cells were observed under microscope (Zeiss Vert A1).

    Article Title: Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats.
    Article Snippet: Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD).. Currently, available therapies are not uniformly effective and lead to serious adverse effects.. Levosimendan (LVS), a calcium sensitizer and an inodilator, manages cardiac failure.


    Article Title: Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Article Snippet: The organoids were stained with fluorescence and photographed under microscope (Zeiss, Vert A1), and the area of live organoids was counted.

    Infection:

    Article Title: Data on the function of CDH17 in pancreatic cancer growth
    Article Snippet: How data was acquired , Microscope (Zeiss, Vert A1), mass spectrometry (Molecular Devices, iD3), GEPIA (Gene Expression Profiling Interactive Analysis: gepia.cancer-pku.cn/)..

    Article Title: Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity.
    Article Snippet: Aims: The present study aimed at exploring the mechanisms behind Klotho regulation in hyperglycemia augmented AKI.. In addition, epigenetic ways to restore the Klotho expression in AKI-diabetes comorbidity have


    Article Title: Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
    Article Snippet: Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their cooverexpression is strongly associated with a poor prognosis.. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.. Inspired by the PROteolysis TArgeting Chimera (PROTAC), a promising pharmacological modality for the selective degradation of proteins, we developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to degrade both β-catenin and STAT3 effectively.

    Article Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Article Snippet: Finally, the cells were observed under microscope (Zeiss Vert A1).

    Article Title: Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats.
    Article Snippet: Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD).. Currently, available therapies are not uniformly effective and lead to serious adverse effects.. Levosimendan (LVS), a calcium sensitizer and an inodilator, manages cardiac failure.


    Article Title: Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Article Snippet: The organoids were stained with fluorescence and photographed under microscope (Zeiss, Vert A1), and the area of live organoids was counted.

    Quantitative RT-PCR:

    Article Title: Data on the function of CDH17 in pancreatic cancer growth
    Article Snippet: How data was acquired , Microscope (Zeiss, Vert A1), mass spectrometry (Molecular Devices, iD3), GEPIA (Gene Expression Profiling Interactive Analysis: gepia.cancer-pku.cn/)..

    Article Title: Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity.
    Article Snippet: Aims: The present study aimed at exploring the mechanisms behind Klotho regulation in hyperglycemia augmented AKI.. In addition, epigenetic ways to restore the Klotho expression in AKI-diabetes comorbidity have


    Article Title: Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
    Article Snippet: Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their cooverexpression is strongly associated with a poor prognosis.. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.. Inspired by the PROteolysis TArgeting Chimera (PROTAC), a promising pharmacological modality for the selective degradation of proteins, we developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to degrade both β-catenin and STAT3 effectively.

    Article Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Article Snippet: Finally, the cells were observed under microscope (Zeiss Vert A1).

    Article Title: Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats.
    Article Snippet: Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD).. Currently, available therapies are not uniformly effective and lead to serious adverse effects.. Levosimendan (LVS), a calcium sensitizer and an inodilator, manages cardiac failure.


    Article Title: Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Article Snippet: The organoids were stained with fluorescence and photographed under microscope (Zeiss, Vert A1), and the area of live organoids was counted.

    Mass Spectrometry:

    Article Title: Data on the function of CDH17 in pancreatic cancer growth
    Article Snippet: How data was acquired , Microscope (Zeiss, Vert A1), mass spectrometry (Molecular Devices, iD3), GEPIA (Gene Expression Profiling Interactive Analysis: gepia.cancer-pku.cn/)..

    Article Title: Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity.
    Article Snippet: Aims: The present study aimed at exploring the mechanisms behind Klotho regulation in hyperglycemia augmented AKI.. In addition, epigenetic ways to restore the Klotho expression in AKI-diabetes comorbidity have


    Article Title: Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
    Article Snippet: Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their cooverexpression is strongly associated with a poor prognosis.. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.. Inspired by the PROteolysis TArgeting Chimera (PROTAC), a promising pharmacological modality for the selective degradation of proteins, we developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to degrade both β-catenin and STAT3 effectively.

    Article Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Article Snippet: Finally, the cells were observed under microscope (Zeiss Vert A1).

    Article Title: Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats.
    Article Snippet: Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD).. Currently, available therapies are not uniformly effective and lead to serious adverse effects.. Levosimendan (LVS), a calcium sensitizer and an inodilator, manages cardiac failure.


    Article Title: Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Article Snippet: The organoids were stained with fluorescence and photographed under microscope (Zeiss, Vert A1), and the area of live organoids was counted.

    Gene Expression:

    Article Title: Data on the function of CDH17 in pancreatic cancer growth
    Article Snippet: How data was acquired , Microscope (Zeiss, Vert A1), mass spectrometry (Molecular Devices, iD3), GEPIA (Gene Expression Profiling Interactive Analysis: gepia.cancer-pku.cn/)..

    Article Title: Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity.
    Article Snippet: Aims: The present study aimed at exploring the mechanisms behind Klotho regulation in hyperglycemia augmented AKI.. In addition, epigenetic ways to restore the Klotho expression in AKI-diabetes comorbidity have


    Article Title: Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
    Article Snippet: Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their cooverexpression is strongly associated with a poor prognosis.. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.. Inspired by the PROteolysis TArgeting Chimera (PROTAC), a promising pharmacological modality for the selective degradation of proteins, we developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to degrade both β-catenin and STAT3 effectively.

    Article Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Article Snippet: Finally, the cells were observed under microscope (Zeiss Vert A1).

    Article Title: Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats.
    Article Snippet: Chronic kidney disease (CKD) is characterized by kidney fibrosis involving epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) accumulation, and often leads to end-stage kidney disease (ESKD).. Currently, available therapies are not uniformly effective and lead to serious adverse effects.. Levosimendan (LVS), a calcium sensitizer and an inodilator, manages cardiac failure.


    Article Title: Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Article Snippet: The organoids were stained with fluorescence and photographed under microscope (Zeiss, Vert A1), and the area of live organoids was counted.



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    Image Search Results


    Journal: Communications Biology

    Article Title: In vivo replication of a fully functional nerve net in a clonally reproducing animal

    doi: 10.1038/s42003-026-11184-x

    Figure Lengend Snippet:

    Article Snippet: A1 (Zeiss) microscope, utilizing the Colibri 7 LED light source and the 38 HE fluorescence filter at 10×.

    Techniques:

    The two pediatric medulloblastoma cell lines ONS76 (p53 wild-type) and UW228-3 (p53-mut.) were exposed to 20 Gy γIR. After the indicated time periods, cells were stained for senescence-associated beta-galactosidase activity (manifested in blue) and documented microscopically in phase contrast ( A ) and brightfield ( B ) using a Zeiss Axio Vert.A1 microscope. With increasing incubation times after irradiation, ONS76 display a strong blue staining and morphological changes, such as an increase in cell and nucleus size, reminiscing of cellular senescence, whereas UW228-3 cells detach from the bottom and die. All pictures were taken with the same 10× objective and the included 100 µm scale bar is representative for all micrographs. The pictures chosen are representative for at least three independent biological experiments. Please note that detached and dead cells are aspirated during the SA-beta-Galactosidase staining procedure and are therefore not present anymore, in contrast to Supplementary Fig. , in which the cells were photographed under culturing conditions.

    Journal: Cell Death Discovery

    Article Title: p53 wild-type/low c-Myc-expressing ONS76 pediatric medulloblastoma cells become senescent after gamma-irradiation and can be eliminated by senolytic substances

    doi: 10.1038/s41420-026-03404-4

    Figure Lengend Snippet: The two pediatric medulloblastoma cell lines ONS76 (p53 wild-type) and UW228-3 (p53-mut.) were exposed to 20 Gy γIR. After the indicated time periods, cells were stained for senescence-associated beta-galactosidase activity (manifested in blue) and documented microscopically in phase contrast ( A ) and brightfield ( B ) using a Zeiss Axio Vert.A1 microscope. With increasing incubation times after irradiation, ONS76 display a strong blue staining and morphological changes, such as an increase in cell and nucleus size, reminiscing of cellular senescence, whereas UW228-3 cells detach from the bottom and die. All pictures were taken with the same 10× objective and the included 100 µm scale bar is representative for all micrographs. The pictures chosen are representative for at least three independent biological experiments. Please note that detached and dead cells are aspirated during the SA-beta-Galactosidase staining procedure and are therefore not present anymore, in contrast to Supplementary Fig. , in which the cells were photographed under culturing conditions.

    Article Snippet: Pictures were taken with 10× or 20× magnification as indicated using the Zeiss Axio Vert.A1 microscope and the associated AxioVision Software (Carl Zeiss MicroImaging GmbH, Göttingen, Germany).

    Techniques: Staining, Activity Assay, Phase Contrast, Brightfield, Microscopy, Incubation, Irradiation